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Artif Cells Nanomed Biotechnol. 2016 Dec;44(8):1933-1937. Epub 2015 Dec 24.

Role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome.

Author information

1
a Department of Gastroenterology , The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an , Shaanxi Province , P.R. China.
2
b Department of Gastroenterology , The Affiliated Hospital of Yan'an University , Yan'an , Shaanxi Province , P.R. China.

Abstract

We aimed to explore the role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome (PI-IBS). Fifty NIH mice were divided into five groups (n = 10). The visceral sensitivities of PI-2W and PI-8W groups significantly exceeded than those of normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Significantly more IL-18 and IL-1β were expressed in PI-2W and PI-8W groups than those in normal control groups (P < 0.05), which was significantly decreased in PI-B group (P < 0.05). Bifidobacterium longum may down-regulate IL-18 and IL-1β expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.

KEYWORDS:

Bifidobacterium longum; NLRP3; inflammasome; postinfectious irritable bowel syndrome

PMID:
26697916
DOI:
10.3109/21691401.2015.1111238
[Indexed for MEDLINE]

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