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BioData Min. 2015 Dec 22;8:44. doi: 10.1186/s13040-015-0075-z. eCollection 2015.

Non-coding yet non-trivial: a review on the computational genomics of lincRNAs.

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Molecular Biosciences and Bioengineering Graduate Program, University of Hawaii at Manoa, Honolulu, HI 96822 USA ; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813 USA.
Laboratory of Immunology and Signal Transduction, Chaminade University of Honolulu, Honolulu, HI 96816 USA.
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 USA.


Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known mechanisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively.

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