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Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1742-5. doi: 10.1002/anie.201509065. Epub 2015 Dec 22.

Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes.

Author information

1
School of Chemistry, The University of Sydney, NSW, 2006, Australia.
2
Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW, 2010, Australia.
3
School of Medical Sciences, UNSW Australia, NSW, 2052, Australia.
4
School of Chemistry and Physics, The University of Adelaide, SA, 5005, Australia.
5
Advanced Photon Source, X-ray Science Division, Argonne National Laboratory, Argonne, IL, 60439, USA.
6
Charles Perkins Centre, The University of Sydney, NSW, 2006, Australia.
7
School of Chemistry, The University of Sydney, NSW, 2006, Australia. peter.lay@sydney.edu.au.

Abstract

Chromium(III) nutritional supplements are widely consumed for their purported antidiabetic activities. X-ray fluorescence microscopy (XFM) and X-ray absorption near-edge structure (XANES) studies have now shown that non-toxic doses of [Cr3 O(OCOEt)6 (OH2 )3 ](+) (A), a prospective antidiabetic drug that undergoes similar H2 O2 induced oxidation reactions in the blood as other Cr supplements, was also oxidized to carcinogenic Cr(VI) and Cr(V) in living cells. Single adipocytes treated with A had approximately 1 μm large Cr hotspots containing Cr(III) , Cr(V) , and Cr(VI) (primarily Cr(VI) thiolates) species. These results strongly support the hypothesis that the antidiabetic activity of Cr(III) and the carcinogenicity of Cr(VI) compounds arise from similar mechanisms involving highly reactive Cr(VI) and Cr(V) intermediates, and highlight concerns over the safety of Cr(III) nutritional supplements.

KEYWORDS:

X-ray fluorescence microscopy; adipocytes; cancer; chromium; oxidation

PMID:
26696553
DOI:
10.1002/anie.201509065
[Indexed for MEDLINE]

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