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J Hematol Oncol. 2015 Dec 21;8:130. doi: 10.1186/s13045-015-0227-0.

Bispecific antibodies and their applications.

Fan G1,2, Wang Z3, Hao M4,5, Li J6,7.

Author information

1
National Center for Clinical Laboratories, Beijing Hospital, No 1 Dahua Road, Dongdan, Beijing, 100730, China. gaoweifan163@163.com.
2
Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. gaoweifan163@163.com.
3
Shunyi District Maternal and Child Health Hospital of Beijing City, Beijing, 101300, China. wangzujian0714@163.com.
4
National Center for Clinical Laboratories, Beijing Hospital, No 1 Dahua Road, Dongdan, Beijing, 100730, China. haomingju@163.com.
5
Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. haomingju@163.com.
6
National Center for Clinical Laboratories, Beijing Hospital, No 1 Dahua Road, Dongdan, Beijing, 100730, China. jmli@nccl.org.cn.
7
Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. jmli@nccl.org.cn.

Abstract

Bispecific antibodies (BsAbs) recognize two different epitopes. This dual specificity opens up a wide range of applications, including redirecting T cells to tumor cells, blocking two different signaling pathways simultaneously, dual targeting of different disease mediators, and delivering payloads to targeted sites. The approval of catumaxomab (anti-EpCAM and anti-CD3) and blinatumomab (anti-CD19 and anti-CD3) has become a major milestone in the development of bsAbs. Currently, more than 60 different bsAb formats exist, some of them making their way into the clinical pipeline. This review summarizes diverse formats of bsAbs and their clinical applications and sheds light on strategies to optimize the design of bsAbs.

PMID:
26692321
PMCID:
PMC4687327
DOI:
10.1186/s13045-015-0227-0
[Indexed for MEDLINE]
Free PMC Article

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