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Biochim Biophys Acta. 2016 May;1862(5):939-44. doi: 10.1016/j.bbadis.2015.12.011. Epub 2015 Dec 12.

Intracerebral hemorrhage and cognitive impairment.

Author information

1
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Neurology Department, Zhongnan Hospital, Wuhan University, Wuhan 430071, China. Electronic address: lxiong2@partners.org.
2
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: yreijmer@mgh.harvard.edu.
3
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: acharidimou@mgh.harvard.edu.
4
Department of Neurology and Stroke Unit, Hôpital Roger Salengro, Lille University Hospital, Lille Cedex 59037, France. Electronic address: charlotte.cordonnier@chru-lille.fr.
5
J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: aviswanathan1@partners.org.

Abstract

Vascular cognitive impairment and vascular dementia are composed of cognitive deficits resulted from a range of vascular lesions and pathologies, including both ischemic and hemorrhagic. However the contribution of spontaneous intracerebral hemorrhage presumed due to small vessel diseases on cognitive impairment is underestimated, in contrast to the numerous studies about the role of ischemic vascular disorders on cognition. In this review we summarize recent findings from clinical studies and appropriate basic science research to better elucidate the role and possible mechanisms of intracerebral hemorrhage in cognitive impairment and dementia. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

KEYWORDS:

Cognitive impairment; Dementia; Intracerebral hemorrhage; Neurodegenerative pathology; Small vessel disease

PMID:
26692171
DOI:
10.1016/j.bbadis.2015.12.011
[Indexed for MEDLINE]
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