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Nat Neurosci. 2016 Feb;19(2):220-2. doi: 10.1038/nn.4199. Epub 2015 Dec 21.

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain.

Author information

1
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
2
Pain Research Center and Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.

Abstract

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

PMID:
26691834
PMCID:
PMC4889808
DOI:
10.1038/nn.4199
[Indexed for MEDLINE]
Free PMC Article

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