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Nat Neurosci. 2016 Feb;19(2):316-9. doi: 10.1038/nn.4215. Epub 2015 Dec 21.

Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex.

Kondo S1,2, Ohki K1,2,3.

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Department of Molecular Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
CREST, Japan Science and Technology Agency, Kawaguchi, Japan.
Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan.


It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LGN axons terminating in V1 and found that LGN axons projecting to layer 4 were generally less tuned for orientation than axons projecting to more superficial layers of V1. We also found several differences in response properties between LGN axons and V1 neurons in layer 4. These results suggest that orientation selectivity of mouse V1 may not simply be inherited from LGN inputs, but could also depend on thalamocortical or V1 circuits.

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