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Bioorg Med Chem Lett. 2016 Jan 15;26(2):440-444. doi: 10.1016/j.bmcl.2015.11.096. Epub 2015 Nov 27.

Anti-inflammatory properties of quebecol and its derivatives.

Author information

1
Département de Chimie and PROTEO, Université Laval, 1045 avenue de la Médecine, Québec G1V 0A6, Canada.
2
Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 rue de la Terrasse, Québec G1V 0A6, Canada.
3
Département de Chimie and PROTEO, Université Laval, 1045 avenue de la Médecine, Québec G1V 0A6, Canada. Electronic address: normand.voyer@chm.ulaval.ca.

Abstract

Herein we report our results on the anti-inflammatory activity of quebecol, a polyphenolic compound discovered in maple syrup. Bioassays demonstrated that quebecol has an anti-inflammatory effect on LPS-induced NF-κB activation and inhibits the secretion of two pro-inflammatory cytokines, IL-6 and TNF-α. We also prepared and tested precursors of quebecol and its derivatives corresponding to its substructures of interest, with the aim to study the structure-activity relationships. Comparing the results obtained for all tested compounds allowed the identification of the main moiety responsible for the anti-inflammatory activity of quebecol.

KEYWORDS:

Anti-inflammatory activity; Inhibition of NF-κB activation; Inhibition of cytokine secretion; Natural polyphenol; Quebecol

PMID:
26691759
DOI:
10.1016/j.bmcl.2015.11.096
[Indexed for MEDLINE]

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