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Eur J Immunol. 2016 Apr;46(4):993-1003. doi: 10.1002/eji.201546073. Epub 2016 Jan 20.

CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation.

Author information

1
Institute of Immunology, Hannover Medical School, Hannover, Germany.
2
Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Abstract

The cell surface receptor CD155 influences a variety of immune processes by binding to its ligands CD226, CD96, or TIGIT. Here, we report that the interaction of CD155 with CD226 in the thymus of BALB/c mice has a dual function. It directly influences the dwell time of memory-like CD8(+) T cells, while it is indirectly involved in generating these cells. It was shown earlier that a massive emergence of memory-like CD8 T cells in thymus crucially depends on abundant IL-4, secreted in steady state by iNKT2 (where iNKT is invariant NKT) cells, a subclass of iNKT cells. Here, we show that absence of either CD155 or CD226 in BALB/c mice causes a profound shift in the iNKT subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells. This shift results in a drop of available IL-4 and creates a scenario similar to that observed in C57BL/6 mice, where iNKT1 cells predominate and iNKT2 cells are much less frequent when compared with BALB/c mice. Yet also in C57BL/6 mice, lack of CD155 or CD226 provokes a further decline in iNKT2 cells, suggesting that the observed effects are not restricted to a particular inbred strain.

KEYWORDS:

CD155; CD226; IL-4; Innate CD8+ T cells; NKT cells

PMID:
26689152
DOI:
10.1002/eji.201546073
[Indexed for MEDLINE]
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