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Neuron. 2015 Dec 16;88(6):1157-1164. doi: 10.1016/j.neuron.2015.10.049.

The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158-0822, USA.
2
Janelia Research Campus of HHMI, 19700 Helix Dr. Ashburn, VA 20147, USA.
3
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158-0822, USA. Electronic address: graeme.davis@ucsf.edu.

Abstract

It is now appreciated that the brain is immunologically active. Highly conserved innate immune signaling responds to pathogen invasion and injury and promotes structural refinement of neural circuitry. However, it remains generally unknown whether innate immune signaling has a function during the day-to-day regulation of neural function in the absence of pathogens and irrespective of cellular damage or developmental change. Here we show that an innate immune receptor, a member of the peptidoglycan pattern recognition receptor family (PGRP-LC), is required for the induction and sustained expression of homeostatic synaptic plasticity. This receptor functions presynaptically, controlling the homeostatic modulation of the readily releasable pool of synaptic vesicles following inhibition of postsynaptic glutamate receptor function. Thus, PGRP-LC is a candidate receptor for retrograde, trans-synaptic signaling, a novel activity for innate immune signaling and the first known function of a PGRP-type receptor in the nervous system of any organism.

PMID:
26687223
PMCID:
PMC4718712
DOI:
10.1016/j.neuron.2015.10.049
[Indexed for MEDLINE]
Free PMC Article

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