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Eur J Epidemiol. 2016 Feb;31(2):197-210. doi: 10.1007/s10654-015-0098-2. Epub 2015 Dec 19.

Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium.

Author information

1
Univ. Bordeaux, ISPED, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France. cecile.delcourt@isped.fr.
2
INSERM, Centre INSERM U897-Epidemiologie-Biostatistique, 33000, Bordeaux, France. cecile.delcourt@isped.fr.
3
Univ. Bordeaux, ISPED, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France.
4
INSERM, Centre INSERM U897-Epidemiologie-Biostatistique, 33000, Bordeaux, France.
5
Service d'Ophtalmologie, CHU de Bordeaux, 33000, Bordeaux, France.
6
Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
7
Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
8
NIHR Biomedical Research Centre, Moorfields Eye Hospital, NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK.
9
Department of Ophthalmology, Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
10
Department of Ophthalmology, University of Padua, Padua, Italy.
11
Department of Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
12
Department Ophthalmology, University Medical Center, Mainz, Germany.
13
Centre for Experimental Medicine, Queen's University of Belfast, Belfast, UK.
14
INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, 21000, Dijon, France.
15
CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, 21000, Dijon, France.
16
Université de Bourgogne, Centre des Sciences du Goût et de l'Alimentation, 21000, Dijon, France.
17
Laboratory of Research and Clinical Applications in Ophthalmology, Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
18
Vienna Reading Center, Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
19
Research Unit of Ophthalmology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
20
Department of Ophthalmology, Odense University Hospital, 5000, Odense, Denmark.
21
Service d'ophtalmologie, Centre Hospitalier Intercommunal de Creteil, CRC, CRB, Universite Paris Est, Creteil, France.
22
Department of Ophthalmology, CHU, 21000, Dijon, France.
23
Institut de la Vision, UPMC Univ Paris 06, UMR_S 968, Paris, 75012, France.
24
INSERM, U968, 75012, Paris, France.
25
CNRS, UMR_7210, 75012, Paris, France.
26
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, INSERM-DHOS CIC 1423, 75012, Paris, France.
27
Fondation Ophtalmologique Rothschild, 75019, Paris, France.
28
Institute of Ophthalmology, University College London, London, EC1V 9EL, UK.
29
INSERM, U1061, 34093, Montpellier, France.
30
Univ Montpellier 1, 34000, Montpellier, France.
31
Department of Ophthalmology, Gui De Chauliac Hospital, 34000, Montpellier, France.
32
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
33
University of Tampere School of Medicine, Tampere, Finland.
34
Clinical Epidemiology, Institute of Epidemiology and Social Medicine, University Münster, 48129, Münster, Germany.
35
INSERM, U1018, Centre for Research in Epidemiology and Population Health (CESP), Epidemiology of Occupational and Social Determinants of Health, Villejuif, France.
36
Université de Versailles Saint-Quentin, Villejuif, France.
37
Northern State Medical University, Arkhangelsk, Russia.
38
Institute of Human Genetics, Technische Universität München, 81675, Munich, Germany.
39
Population, Policy and Practice Programme, UCL Institute of Child Health, London, WC1N 1EH, UK.
40
Ulverscroft Vision Research Group, UCL Institute of Child Health, London, WC1N 1EH, UK.
41
Department of Ophthalmology, GRADE Reading Center, University of Bonn, 53127, Bonn, Germany.
42
Center of Ophthalmology, University Hospital Cologne, 50924, Cologne, Germany.
43
Department of Ophthalmology, University Hospital of North Norway, Tromsø, Norway.
44
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
45
Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands.
46
Department of Clinical Genetics, Academic Medical Centre, Amsterdam, The Netherlands.
47
Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal.
48
Faculty of Medicine (FMUC), University of Coimbra, Coimbra, Portugal.
49
Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal.
50
Department of Ophthalmology, Inselspital, University Hospital, University of Bern, Bern, Switzerland.
51
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
52
Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Abstract

The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases. Coordinating these existing data will allow a detailed study of the risk factors and consequences of eye diseases and visual impairment, including study of international geographical variation which is not possible in individual studies. It is expected that collaborative work on these existing data will provide additional knowledge, despite the fact that the risk factors and the methods for collecting them differ somewhat among the participating studies. Most studies also include biobanks of various biological samples, which will enable identification of biomarkers to detect and predict occurrence and progression of eye diseases. This article outlines the rationale of the consortium, its design and presents a summary of the methodology.

KEYWORDS:

Epidemiology; Europe; Eye diseases; Ophthalmology; Prevalence; Risk factors

PMID:
26686680
DOI:
10.1007/s10654-015-0098-2
[Indexed for MEDLINE]

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