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DNA Repair (Amst). 2016 Feb;38:84-93. doi: 10.1016/j.dnarep.2015.11.024. Epub 2015 Dec 2.

Roles for mismatch repair family proteins in promoting meiotic crossing over.

Author information

1
Department of Molecular Biology and Genetics, Cornell University, 457 Biotechnology Building, Ithaca, NY 14853-2703, USA.
2
Department of Molecular Biology and Genetics, Cornell University, 457 Biotechnology Building, Ithaca, NY 14853-2703, USA. Electronic address: eea3@cornell.edu.

Abstract

The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the asymmetric cleavage of double Holliday junctions (dHJ) to form crossovers. This review discusses how meiotic roles for Msh4-Msh5 and Mlh1-Mlh3 do not fit paradigms established for post-replicative MMR. We also outline models used to explain how these factors promote the formation of meiotic crossovers required for the accurate segregation of chromosome homologs during the Meiosis I division.

KEYWORDS:

Crossing over; Holliday junction resolution; Meiosis; Mlh1-Mlh3; Msh4-Msh5

PMID:
26686657
PMCID:
PMC4740264
DOI:
10.1016/j.dnarep.2015.11.024
[Indexed for MEDLINE]
Free PMC Article

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