Format

Send to

Choose Destination
ACS Chem Biol. 2016 Mar 18;11(3):654-68. doi: 10.1021/acschembio.5b00942. Epub 2015 Dec 31.

Protein Arginine Methylation and Citrullination in Epigenetic Regulation.

Author information

1
Department of Chemistry, The Scripps Research Institute , 130 Scripps Way, Jupiter, Florida 33458, United States.
2
Department of Biochemistry and Molecular Pharmacology, UMass Medical School , 364 Plantation Street, Worcester, Massachusetts 01605, United States.
3
Program in Chemical Biology, UMass Medical School , 364 Plantation Street, Worcester, Massachusetts 01605, United States.

Abstract

The post-translational modification of arginine residues represents a key mechanism for the epigenetic control of gene expression. Aberrant levels of histone arginine modifications have been linked to the development of several diseases including cancer. In recent years, great progress has been made in understanding the physiological role of individual arginine modifications and their effects on chromatin function. The present review aims to summarize the structural and functional aspects of histone arginine modifying enzymes and their impact on gene transcription. We will discuss the potential for targeting these proteins with small molecules in a variety of disease states.

PMID:
26686581
PMCID:
PMC4802296
DOI:
10.1021/acschembio.5b00942
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center