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Pediatr Nephrol. 2016 Oct;31(10):1553-60. doi: 10.1007/s00467-015-3296-y. Epub 2015 Dec 21.

Regenerating a kidney in a lymph node.

Author information

1
McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh School of Medicine, 450 Technology Drive. Suite 300, Pittsburgh, PA, 15219, USA. francipa@pitt.edu.
2
Ri.MED Foundation, 90133, Palermo, Italy. francipa@pitt.edu.
3
McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh School of Medicine, 450 Technology Drive. Suite 300, Pittsburgh, PA, 15219, USA.

Abstract

The ultimate treatment for end-stage renal disease (ESRD) is orthotopic transplantation. However, the demand for kidney transplantation far exceeds the number of available donor organs. While more than 100,000 Americans need a kidney, only 17,000 people receive a kidney transplant each year (National Kidney Foundation's estimations). In recent years, several regenerative medicine/tissue engineering approaches have been exploited to alleviate the kidney shortage crisis. Although these approaches have yielded promising results in experimental animal models, the kidney is a complex organ and translation into the clinical realm has been challenging to date. In this review, we will discuss cell therapy-based approaches for kidney regeneration and whole-kidney tissue engineering strategies, including our innovative approach to regenerate a functional kidney using the lymph node as an in vivo bioreactor.

KEYWORDS:

Cell-based regeneration; Kidney; Lymph node; Organogenesis; Whole-organ engineering

PMID:
26686504
PMCID:
PMC4916029
DOI:
10.1007/s00467-015-3296-y
[Indexed for MEDLINE]
Free PMC Article

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