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Eur J Obstet Gynecol Reprod Biol. 2016 Jan;196:57-9. doi: 10.1016/j.ejogrb.2015.11.022. Epub 2015 Nov 24.

Clinical significance of neonatal menstruation.

Author information

1
Leuven Institute for Fertility and Embryology, Leuven, Belgium. Electronic address: ivo.brosens@med.kuleuven.be.
2
Department of Gynaecology, Obstetrics and Urology, Sapienza, University of Rome, Italy.

Abstract

Past studies have clearly shown the existence of a spectrum of endometrial progesterone responses in neonatal endometrium, varying from proliferation to full decidualization with menstrual-like shedding. The bleedings represent, similar to what occurs in adult menstruation, a progesterone withdrawal bleeding. Today, the bleeding is completely neglected and considered an uneventful episode of no clinical significance. Yet clinical studies have linked the risk of bleeding to a series of events indicating fetal distress. The potential link between the progesterone response and major adolescent disorders requires to be investigated by prospective studies.

KEYWORDS:

Adolescent endometriosis; Endometrial bleeding; Fetal distress; Neonate; Preeclampsia

PMID:
26685798
DOI:
10.1016/j.ejogrb.2015.11.022
[Indexed for MEDLINE]

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