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Eur Arch Otorhinolaryngol. 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19.

Salivary acinic cell carcinoma: reappraisal and update.

Author information

1
Otorhinolaryngology-Head and Neck Surgery and Leuven Cancer Institute, Department of Oncology-Section Head and Neck Oncology, University Hospitals Leuven, KU Leuven, Leuven, Belgium. vincent.vanderpoorten@uzleuven.be.
2
European Salivary Gland Society, Geneva, Switzerland. vincent.vanderpoorten@uzleuven.be.
3
School of Dentistry, University of Liverpool, Liverpool, UK.
4
Pathology Department, Liverpool Clinical Laboratories, Liverpool, UK.
5
Southern California Permanente Medical Group, Woodland Hills, CA, USA.
6
Department of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
7
Department of Imaging and Pathology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
8
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
9
Department of Pathology, Faculty of Medicine in Plzen, Charles, University Prague, Prague, Czech Republic.
10
European Salivary Gland Society, Geneva, Switzerland.
11
Department of Pathology, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden.
12
Department of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
13
University Pathologists, Fall River, MA, USA.
14
Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal.
15
Department of Pathology, Beth Israel Medical Center, New York, NY, USA.
16
Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA.
17
University of Udine School of Medicine, Udine, Italy.
18
Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Abstract

Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

KEYWORDS:

Acinic cell carcinoma; Mammary analog secretory carcinoma; Pathology; Prognosis; Salivary glands; Therapy

PMID:
26685679
DOI:
10.1007/s00405-015-3855-7
[Indexed for MEDLINE]

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