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Biorheology. 2015;52(5-6):353-77. doi: 10.3233/BIR-15085.

Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation.

Fan Z1, Ley K1,2.

Author information

1
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
2
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.

Abstract

Integrins are a group of heterodimeric transmembrane receptors that play essential roles in cell-cell and cell-matrix interaction. Integrins are important in many physiological processes and diseases. Integrins acquire affinity to their ligand by undergoing molecular conformational changes called activation. Here we review the molecular biomechanics during conformational changes of integrins, integrin functions in leukocyte biorheology (adhesive functions during rolling and arrest) and molecules involved in integrin activation.

KEYWORDS:

GPCR; PSGL-1; RIAM; Rap-1; Talin; kindlin-3

PMID:
26684674
PMCID:
PMC4869873
DOI:
10.3233/BIR-15085
[Indexed for MEDLINE]
Free PMC Article

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