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Int J Immunopathol Pharmacol. 2016 Jun;29(2):267-73. doi: 10.1177/0394632015590949. Epub 2015 Dec 18.

Evaluation of an oral appliance in patients with mild to moderate obstructive sleep apnea syndrome intolerant to continuous positive airway pressure use: Preliminary results.

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Department of Basic Medical Science, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Department of Basic Medical Science, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy
Department of Morphologic and Surgical Sciences, Insubria University, Varese, Italy.
Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Department of Biomedical, Surgical and Dental Sciences, Unit of Orthodontics and Paediatric Dentistry, University of Milan, Milan, Italy.


Obstructive sleep apnea syndrome (OSAS) is a phenomenon of repeated, episodic reduction, or cessation of airflow (hypopnea/apnea) as a result of upper airways obstruction. First-line treatment in younger children is adenotonsillectomy, although other available treatment options in middle-aged adults include continuous positive airways pressure (CPAP) and airway adjuncts. Oral appliances (OA) are a viable treatment alternative in patients with OSAS.The objective of this study was to assess, in a 1-year follow-up study, an OA in OSAS patients. The participants were subjected to polysomnographic examination with a validated device (MicroMESAM). Eight participants were fitted with a Thornton Adjustable Positioner (TAP). The participants were asked to wear the test appliance for 7 nights, and in case of compliance, for 6 months. The selected patients record their usage of the appliance and any adverse effects in a treatment journal. The research focused on the following outcomes: sleep apnea (i.e. reduction in the apnea/hypopnea index) and the effect of oral appliances on daytime function.In conclusion, the results suggest that OA have a definite role in the treatment of snoring and sleep apnea.


Thornton Adjustable Positioner; apnea-hypopnea index; continuous positive airway pressure; obstructive sleep apnea syndrome; oral appliance

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