Posterior reversible encephalopathy syndrome with thalamic involvement during vasopressor treatment of vertebrobasilar vasospasm after subarachnoid hemorrhage

J Neurointerv Surg. 2016 Nov;8(11):e45. doi: 10.1136/neurintsurg-2015-012103.rep. Epub 2015 Dec 18.

Abstract

Hemodynamic augmentation is the primary medical intervention employed to reverse neurological deficits associated with vasospasm and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. Failure to improve despite induced hypertension (IH) may raise concern for persistent hypoperfusion and prompt even more aggressive blood pressure augmentation. However, posterior reversible encephalopathy syndrome (PRES) is a hyperperfusion syndrome reported as a rare complication of IH that may confound this picture. We report a case of PRES with prominent thalamic involvement and impaired level of consciousness secondary to blood pressure augmentation for the treatment of symptomatic vertebrobasilar vasospasm. Recognition of this syndrome in distinction to worsening ischemia is particularly critical, as normalization of blood pressure should lead to rapid clinical improvement.

Keywords: Blood Pressure; Complication; Hemorrhage; MRI; Subarachnoid.

Publication types

  • Case Reports

MeSH terms

  • Blood Pressure
  • Consciousness Disorders / chemically induced
  • Diagnosis, Differential
  • Epilepsy, Tonic-Clonic / chemically induced
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Phenylephrine / adverse effects
  • Phenylephrine / therapeutic use
  • Posterior Leukoencephalopathy Syndrome / chemically induced*
  • Posterior Leukoencephalopathy Syndrome / diagnostic imaging
  • Posterior Leukoencephalopathy Syndrome / therapy*
  • Subarachnoid Hemorrhage / complications*
  • Thalamus / diagnostic imaging
  • Thalamus / physiopathology*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Vasoconstrictor Agents / adverse effects*
  • Vasoconstrictor Agents / therapeutic use
  • Vasospasm, Intracranial / complications
  • Vasospasm, Intracranial / drug therapy*
  • Vasospasm, Intracranial / etiology

Substances

  • Vasoconstrictor Agents
  • Phenylephrine