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Biomed Res Int. 2015;2015:481621. doi: 10.1155/2015/481621. Epub 2015 Nov 23.

Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men.

Author information

1
Department of Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China ; Department of Aging, Antiaging and Cognitive Function, Shanghai Institute of Geriatrics and Gerontology, Shanghai 200040, China.
2
Department of Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
3
Research Center of Aging and Medicine, Department of Aging and Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
4
Department of Aging, Antiaging and Cognitive Function, Shanghai Institute of Geriatrics and Gerontology, Shanghai 200040, China ; Research Center of Aging and Medicine, Department of Aging and Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
5
Department of Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China ; Department of Aging, Antiaging and Cognitive Function, Shanghai Institute of Geriatrics and Gerontology, Shanghai 200040, China ; Research Center of Aging and Medicine, Department of Aging and Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.

Abstract

BACKGROUND:

Advancing age, chronic inflammation, oxidative damage, and disorders of lipid metabolism are positively linked to the late-life cognitive impairment. Serum biomarkers may be associated with the cognitive status in older men.

METHODS:

440 old male subjects with different cognitive functions were recruited to investigate probable serum markers. Pearson Chi-Squared test, univariate analysis, and multivariate logistic regression analysis were performed to evaluate biomarkers which may be associated with cognitive status.

RESULTS:

Levels of fundus atherosclerosis (AS) (P < 0.001), age (P < 0.001), serum biomarkers peroxidase (POD) (P = 0.026) and interleukin-6 (IL-6) (P = 0.001), serum levels of high-density lipoprotein cholesterol (HDL-C) (P < 0.001), apolipoprotein A2 (ApoA2) (P = 0.001), and ApoC2 (P = 0.005) showed significant differences. Compared to group 3, ApoA1 in group 1 (OR = 1.30, 95% CI 1.01-1.67) and group 2 (OR = 1.47, 95% CI 1.11-1.94) were higher, while ApoA2 were lower (group 1: OR = 0.43, 95% CI 0.18-1.02; group 2: OR = 0.21, 95% CI 0.08-0.54) after adjusting for control variables.

CONCLUSION:

The results demonstrated that age, AS levels, POD, IL-6, HDL-C, ApoA2, and ApoC2 were significantly related to cognitive status. Moreover, ApoA1 and ApoA2 were independently associated with cognitive impairment and late-life dementia.

PMID:
26682220
PMCID:
PMC4670907
DOI:
10.1155/2015/481621
[Indexed for MEDLINE]
Free PMC Article

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