Format

Send to

Choose Destination
Biomed Res Int. 2015;2015:187809. doi: 10.1155/2015/187809. Epub 2015 Nov 23.

Circadian Control of Global Transcription.

Author information

1
College of Life Science & Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China ; Key Laboratory of Molecular Biophysics of the Ministry of Education, Wuhan, Hubei 430074, China.

Abstract

Circadian rhythms exist in most if not all organisms on the Earth and manifest in various aspects of physiology and behavior. These rhythmic processes are believed to be driven by endogenous molecular clocks that regulate rhythmic expression of clock-controlled genes (CCGs). CCGs consist of a significant portion of the genome and are involved in diverse biological pathways. The transcription of CCGs is tuned by rhythmic actions of transcription factors and circadian alterations in chromatin. Here, we review the circadian control of CCG transcription in five model organisms that are widely used, including cyanobacterium, fungus, plant, fruit fly, and mouse. Comparing the similarity and differences in the five organisms could help us better understand the function of the circadian clock, as well as its output mechanisms adapted to meet the demands of diverse environmental conditions.

PMID:
26682214
PMCID:
PMC4670846
DOI:
10.1155/2015/187809
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Publishing Corporation Icon for PubMed Central
Loading ...
Support Center