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Surg Neurol Int. 2015 Nov 25;6(Suppl 25):S628-32. doi: 10.4103/2152-7806.170464. eCollection 2015.

Cranial and spinal leptomeningeal dissemination in esthesioneuroblastoma: Two reports of distant central nervous system metastasis and rationale for treatment.

Author information

1
Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah 84132, USA.
2
Department of Neurosurgery, Loma Linda University, Loma Linda, California 92354, USA.

Abstract

BACKGROUND:

Esthesioneuroblastoma is a locally aggressive cancer of the nasal cavity. While systemic metastasis can occur in 10-30% of patients, there are only six reported cases of distal metastasis from leptomeningeal dissemination.

CASE DESCRIPTION:

The authors report two cases of esthesioneuroblastoma treated previously with multimodal therapy in which distal metastatic recurrence was found and describe their treatment protocol, which has resulted in long-term success.

CONCLUSION:

Understanding the drivers of leptomeningeal dissemination in more prevalent primary neuroectodermal tumors may hold the key to developing successful treatment algorithms for this disease.

KEYWORDS:

Carcinomatosis; chemotherapy; esthesioneuroblastoma; leptomeningeal dissemination; olfactory neuroblastoma; primary neuroectodermal tumor; radiation; surgery

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