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Stem Cells Int. 2016;2016:9682757. doi: 10.1155/2016/9682757. Epub 2015 Nov 22.

How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?

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Department of Cardiology, Daping Hospital, Third Military Medical University, 10 Changjiangzhilu Road, Chongqing 400042, China.
Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 14190, USA.


Mesenchymal stem cell (MSC) is an intensely studied stem cell type applied for cardiac repair. For decades, the preclinical researches on animal model and clinical trials have suggested that MSC transplantation exerts therapeutic effect on ischemic heart disease. However, there remain major limitations to be overcome, one of which is the very low survival rate after transplantation in heart tissue. Various strategies have been tried to improve the MSC survival, and many of them showed promising results. In this review, we analyzed the studies in recent years to summarize the methods, effects, and mechanisms of the new strategies to address this question.

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