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J Pharm Bioallied Sci. 2015 Oct-Dec;7(4):289-92. doi: 10.4103/0975-7406.168028.

Antidiabetic activity of ethanolic extract of Cyperus rotundus rhizomes in streptozotocin-induced diabetic mice.

Author information

1
Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
2
Department of Pharmaceutical Sciences, Bharat Institute of Technology, Meerut, Uttar Pradesh, India.

Abstract

OBJECTIVE:

In the present investigation, ethanolic extract of Cyperus rotundus (EECR) rhizomes was evaluated for antidiabetic activity in streptozotocin (STZ)-induced diabetic swiss mice.

MATERIALS AND METHODS:

After administration of EECR extract for 3 weeks, the body weight, blood glucose, biomarker enzymes (serum glutamic pyruvic transaminase [SGPT] and serum glutamic oxaloacetic transaminase [SGOT]), and plasma lipid levels were measured in STZ-induced diabetic mice.

RESULTS:

The ethanolic extract at dose levels of 250 and 500 mg/kg body weight revealed significant antidiabetic activity, improvement in body weight, and reduction in elevated biochemical parameters such as SGPT, SGOT, cholesterol, and triglyceride levels.

CONCLUSION:

These experimental findings seemed to indicate the use of this plant in traditional Indian medicine for the treatment of diabetes.

KEYWORDS:

Antidiabetic activity; Cyperus rotundus; phytochemical analysis; rhizome; streptozotocin

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