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Pediatrics. 2016 Jan;137(1). doi: 10.1542/peds.2015-1352. Epub 2015 Dec 17.

Fatal Myocarditis Associated With HHV-6 Following Immunosuppression in Two Children.

Author information

1
Divsion of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis, Minnesota; and.
2
Biocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany.
3
Divsion of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis, Minnesota; and lundx072@umn.edu.

Abstract

Fatal myocarditis is a rare complication in immunosuppressed children. Recent reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign infection in childhood, with myocarditis. HHV-6 can reactivate during periods of immunosuppression. Here, we report 2 cases in which children were immunosuppressed, one for treatment of Evans syndrome and the other post hematopoietic stem cell transplantation, who developed rapid and fatal HHV-6-associated myocarditis. These cases suggest that HHV-6 infection should be considered as an etiology of myocarditis in immunosuppressed patients regardless of correlating blood levels. Early treatment of HHV-6 in patients with myocarditis could improve morbidity and mortality.

PMID:
26681781
PMCID:
PMC5545791
DOI:
10.1542/peds.2015-1352
[Indexed for MEDLINE]
Free PMC Article

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