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Diabetes Care. 2016 Mar;39(3):363-70. doi: 10.2337/dc15-0858. Epub 2015 Dec 17.

Severe Hypoglycemia Requiring Medical Intervention in a Large Cohort of Adults With Diabetes Receiving Care in U.S. Integrated Health Care Delivery Systems: 2005-2011.

Author information

1
Marshfield Clinic, Marshfield, WI pathak.ram@marshfieldclinic.org.
2
Kaiser Permanente Colorado, Institute for Health Research, Denver, CO.
3
Department of Medicine, University of Minnesota, Minneapolis, MN.
4
Virginia Commonwealth University, Richmond, VA Henry Ford Health System, Detroit, MI.
5
Henry Ford Health System, Detroit, MI.
6
HealthPartners Institute for Education and Research, Minneapolis, MN.
7
Kaiser Permanente Hawaii, Honolulu, HI.
8
Kaiser Permanente Northwest, Portland, OR.
9
Kaiser Permanente Southern California, Pasadena, CA.
10
Kaiser Permanente Northern California, Oakland, CA.
11
Johns Hopkins University, Baltimore, MD.

Abstract

OBJECTIVE:

Appropriate glycemic control is fundamental to diabetes care, but aggressive glucose targets and intensive therapy may unintentionally increase episodes of hypoglycemia. We quantified the burden of severe hypoglycemia requiring medical intervention in a well-defined population of insured individuals with diabetes receiving care in integrated health care delivery systems across the U.S.

RESEARCH DESIGN AND METHODS:

This observational cohort study included 917,440 adults with diabetes receiving care during 2005 to 2011 at participating SUrveillance, PREvention, and ManagEment of Diabetes Mellitus (SUPREME-DM) network sites. Severe hypoglycemia rates were based on any occurrence of hypoglycemia-related ICD-9 codes from emergency department or inpatient medical encounters and reported overall and by age, sex, comorbidity status, antecedent A1C level, and medication use.

RESULTS:

Annual rates of severe hypoglycemia ranged from 1.4 to 1.6 events per 100 person-years. Rates of severe hypoglycemia were higher among those with older age, chronic kidney disease, congestive heart failure, cardiovascular disease, depression, and higher A1C levels, and in users of insulin, insulin secretagogues, or β-blockers (P < 0.001 for all). Changes in severe hypoglycemia occurrence over time were not clinically significant in the cohort as a whole but were observed in subgroups of individuals with chronic kidney disease, congestive heart failure, and cardiovascular disease.

CONCLUSIONS:

Risk of severe hypoglycemia in clinical settings is considerably higher in identifiable patient subgroups than in randomized controlled trials. Strategies that reduce the risk of hypoglycemia in high-risk patients are needed.

PMID:
26681726
PMCID:
PMC4876672
[Available on 2017-03-01]
DOI:
10.2337/dc15-0858
[Indexed for MEDLINE]
Free PMC Article

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