Format

Send to

Choose Destination
Nat Immunol. 2016 Jan;17(1):26-33. doi: 10.1038/ni.3306.

Molecular control of activation and priming in macrophages.

Author information

1
Department of Cellular and Molecular Medicine and Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.
2
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

Abstract

In tissues, macrophages are exposed to metabolic, homeostatic and immunoregulatory signals of local or systemic origin that influence their basal functions and responses to danger signals. Signal-transduction pathways regulated by extracellular signals are coupled to distinct sets of broadly expressed stimulus-regulated transcription factors whose ability to elicit gene-expression changes is influenced by the accessibility of their binding sites in the macrophage genome. In turn, accessibility of macrophage-specific transcriptional regulatory elements (enhancers and promoters) is specified by transcription factors that determine the macrophage lineage or impose their tissue-specific properties. Here we review recent findings that advance the understanding of mechanisms underlying priming and signal-dependent activation of macrophages and discuss the effect of genetic variation on these processes.

PMID:
26681459
PMCID:
PMC4795476
DOI:
10.1038/ni.3306
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center