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J Med Virol. 2016 Jul;88(7):1103-12. doi: 10.1002/jmv.24450. Epub 2016 Jan 5.

Expanding role of cytomegalovirus as a human pathogen.

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Microbiology Service, Hospital Clínico Universitario, Fundación INCLIVA, Valencia, Spain.
Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.


Cytomegalovirus (CMV) continues to be a leading cause of morbidity and mortality in transplant recipients, despite major advancements in preventative strategies. Antiviral prophylaxis and pre-emptive antiviral therapeutic regimens are associated with a high incidence of late-onset end-organ disease and cause drug-related toxicity when overused. Therefore, the identification of risk factors for CMV replication is required. Genetic and immunological factors that predispose individuals to CMV-related clinical complications have been identified and may be instrumental for optimizing CMV treatment in the future. Evidence suggests a causal pathogenetic link between CMV-related complications and inflammatory diseases in non-canonically immunosuppressed individuals such as patients with lung injury and critically ill and cancer patients. However, a randomized clinical trial is required to determine if a causal relationship exists.


T-cell immunity; critically ill patients; cytomegalovirus; glioblastoma multiforme; host genetics; transplant recipients

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