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BMC Syst Biol. 2015;9 Suppl 6:S6. doi: 10.1186/1752-0509-9-S6-S6. Epub 2015 Dec 9.

A model for gene deregulation detection using expression data.

Abstract

In tumoral cells, gene regulation mechanisms are severely altered. Genes that do not react normally to their regulators' activity can provide explanations for the tumoral behavior, and be characteristic of cancer subtypes. We thus propose a statistical methodology to identify the misregulated genes given a reference network and gene expression data.

PMID:
26679516
PMCID:
PMC4674863
DOI:
10.1186/1752-0509-9-S6-S6
[Indexed for MEDLINE]
Free PMC Article

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