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Mol Nutr Food Res. 2016 Apr;60(4):834-45. doi: 10.1002/mnfr.201500483. Epub 2016 Jan 28.

Exploring the association of dairy product intake with the fatty acids C15:0 and C17:0 measured from dried blood spots in a multipopulation cohort: Findings from the Food4Me study.

Author information

1
Human Nutrition Research Centre and Institute for Health and Society, Newcastle University, Newcastle upon Tyne, UK.
2
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre + (MUMC+), Maastricht, The Netherlands.
3
Institute of Food and Health, University College Dublin (UCD), Belfield, Dublin, Ireland.
4
Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, UK.
5
Department of Nutrition, Food Science and Physiology, University of Navarra, CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (SN-C & JAM), Spain.
6
ZIEL Research Center of Nutrition and Food Sciences, Biochemistry Unit, Technische Universität München, Germany.
7
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
8
National Food and Nutrition Institute (IZZ), Poland.
9
Vitas AS, Olso Innovation Park, Oslo, Norway.
10
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.

Abstract

SCOPE:

The use of biomarkers in the objective assessment of dietary intake is a high priority in nutrition research. The aim of this study was to examine pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) as biomarkers of dairy foods intake.

METHODS AND RESULTS:

The data used in the present study were obtained as part of the Food4me Study. Estimates of C15:0 and C17:0 from dried blood spots and intakes of dairy from a Food Frequency Questionnaire were obtained from participants (n = 1180) across seven countries. Regression analyses were used to explore associations of biomarkers with dairy intake levels and receiver operating characteristic analyses were used to evaluate the fatty acids. Significant positive associations were found between C15:0 and total intakes of high-fat dairy products. C15:0 showed good ability to distinguish between low and high consumers of high-fat dairy products.

CONCLUSION:

C15:0 can be used as a biomarker of high-fat dairy intake and of specific high-fat dairy products. Both C15:0 and C17:0 performed poorly for total dairy intake highlighting the need for caution when using these in epidemiological studies.

KEYWORDS:

Biomarkers; Dairy intake; Dried blood spots; Heptadecanoic acid; Pentadecanoic acid

PMID:
26678873
DOI:
10.1002/mnfr.201500483
[Indexed for MEDLINE]

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