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Headache. 2016 Jan;56(1):215-21. doi: 10.1111/head.12749. Epub 2015 Dec 18.

Cyclic vomiting syndrome versus inborn errors of metabolism: A review with clinical recommendations.

Author information

1
Department of Neurology, UCSF, San Francisco, CA, USA.
2
Department of Pediatrics, UCSF, San Francisco, CA, USA.

Abstract

BACKGROUND:

Inborn errors of metabolism are on the differential for patients presenting with a cyclic vomiting syndrome phenotype. Classes of disorders to consider include: mitochondrial disorders, fatty acid oxidation disorders, urea cycle defects, organic acidurias, and acute intermittent porphyria.

AIM:

This article reviews the metabolic differential diagnosis and approach to screening for inborn errors in children and adults presenting with a cyclic or recurrent vomiting phenotype.

CONCLUSION:

Cyclic vomiting syndrome is thought to be an episodic syndrome that may be associated with migraine. It is a diagnosis of exclusion. Inborn errors of metabolism should be considered in the patient presenting with a recurrent vomiting phenotype. Mitochondrial dysfunction may play a role in cyclic vomiting syndrome, and true mitochondrial disorders can present with a true cyclic vomiting phenotype.

KEYWORDS:

abdominal migraine; cyclic vomiting syndrome; inborn error of metabolism; mitochondriopathy

PMID:
26678622
PMCID:
PMC4728152
DOI:
10.1111/head.12749
[Indexed for MEDLINE]
Free PMC Article

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