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Adv Healthc Mater. 2016 Feb 4;5(3):335-41. doi: 10.1002/adhm.201500740. Epub 2015 Dec 16.

3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Author information

1
ZIK HIKE - Centre for Innovation Competence (Humoral Immune Reactions in Cardiovascular Diseases), Ernst-Moritz-Arndt-University, 17489, Greifswald, Germany.
2
Institute for Physics, University of Greifswald, 17489, Greifswald, Germany.
3
Clinic for Internal Medicine B (Cardiology), University of Greifswald Sauebruchstrasse, 17475, Greifswald, Germany.
4
DZHK (German Centre for Cardiovascular Research) partner site, Greifswald, Germany.

Abstract

3D micropillars generated by photolithography are used as a platform to probe by atomic force microscopy the mechanodynamics of human induced pluripotent stem cell-derived cardiomyocytes. 3D micropillars guide subcellular cytoskeletal modifications of cardiomyocytes and lead to biochemical changes altering beating rate, stiffness, and calcium dynamics of the cells.

KEYWORDS:

3D micropillars; atomic force microscopy; induced pluripotent stem cells; mechanobiology; sarcomeres

PMID:
26676091
DOI:
10.1002/adhm.201500740
[Indexed for MEDLINE]

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