Format

Send to

Choose Destination
BBA Clin. 2015 Jan 16;3:123-5. doi: 10.1016/j.bbacli.2015.01.001. eCollection 2015 Jun.

Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial.

Author information

1
Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, United States ; School of Nutrition and Food Sciences, Louisiana State University, Baton Rouge, United States.
2
Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, United States.

Abstract

BACKGROUND:

Impaired brain glucose metabolism appears to be a potential pathogenic feature of mild cognitive impairment (MCI). This study examined the potential for increasing circulating ketone bodies through medium chain triglyceride (MCT) supplementation, as a means to beneficially modulate brain homeostasis in subjects with MCI.

METHODS:

Six participants with MCI were enrolled in a randomized placebo-controlled trial. Participants received 56 g/day of either medium chain triglycerides (MCTs) or placebo for 24 weeks. Serum β-hydroxybutyrate concentrations, apolipoprotein-E4 status, and cognitive assessments were carried out. Due to the small number of participants only the raw scores were examined.

RESULTS:

Intake of MCT oil increased serum ketone bodies and improved memory, while intake of placebo did not show improvement in any of the cognitive measures tested.

CONCLUSIONS:

Consumption of 56 g/day of MCTs for 24 weeks increases serum ketone concentrations and appears to be a candidate for larger randomized control trials in the future that quantify the modulation of cognitive function through supplementation with ketone precursors, in patients with MCI.

KEYWORDS:

Alzheimer's disease; Ketone bodies; Medium chain triglycerides; Memory; Mild cognitive impairment

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center