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Mol Immunol. 2016 Jan;69:70-6. doi: 10.1016/j.molimm.2015.11.009. Epub 2015 Dec 8.

Expression of DNAM-1 (CD226) on inflammatory monocytes.

Author information

1
Department of Immunology, Faculty of Medicine, Japan; Human Biology Program, School of Integrative and Global Majors, Japan.
2
Department of Immunology, Faculty of Medicine, Japan.
3
Department of Immunology, Faculty of Medicine, Japan; Life Science Center of Tsukuba Advanced Research Alliance (TARA), Japan; Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), University of Tsukuba, 1-1-1, Tennohdai, Tsukuba, Ibaraki 305-8575, Japan; AMED-CREST, AMED, Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyodaku, Tokyo 100-0004, Japan.
4
Department of Immunology, Faculty of Medicine, Japan. Electronic address: kazukos@md.tsukuba.ac.jp.

Abstract

DNAM-1 is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. Although the role of DNAM-1 in the function of T cells and NK cells has been well studied, the expression and function of DNAM-1 on myeloid cells have been incompletely understood. In this study, we investigated expression of DNAM-1 on monocyte subsets in mouse peripheral blood and found that only inflammatory monocytes (iMos), but not patrolling monocytes (pMos), expressed high levels of DNAM-1. In addition, we found that DNAM-1 was highly expressed on iMos, rather than pMos, also in human. Furthermore, we found that DNAM-1 on inflammatory monocytes was involved in cell adhesion to CD155-expressing cells. Therefore, we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule on blood inflammatory monocytes.

KEYWORDS:

Adhesion; DNAM-1 (CD226); Inflammatory monocytes; Patrolling monocytes

PMID:
26675069
DOI:
10.1016/j.molimm.2015.11.009
[Indexed for MEDLINE]

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