Change in brain network connectivity during PACAP38-induced migraine attacks: A resting-state functional MRI study

Faisal Mohammad Amin; Anders Hougaard; Stefano Magon; Mohammad Sohail Asghar; Nur Nabil Ahmad; Egill Rostrup; Till Sprenger; Messoud Ashina

doi:10.1212/WNL.0000000000002261

Change in brain network connectivity during PACAP38-induced migraine attacks: A resting-state functional MRI study

Neurology. 2016 Jan 12;86(2):180-7. doi: 10.1212/WNL.0000000000002261. Epub 2015 Dec 16.

Authors

Faisal Mohammad Amin¹, Anders Hougaard¹, Stefano Magon¹, Mohammad Sohail Asghar¹, Nur Nabil Ahmad¹, Egill Rostrup¹, Till Sprenger¹, Messoud Ashina²

Affiliations

¹ From the Danish Headache Center and Department of Neurology (F.M.A., A.H., M.S.A., N.N.A., M.A.) and the Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine (E.R.), Rigshospitalet Glostrup, University of Copenhagen, Denmark; the Department of Neurology (S.M.), University Hospital Basel, Switzerland; and the Department of Neurology (T.S.), DKD Helios Klinik Wiesbaden, Germany.
² From the Danish Headache Center and Department of Neurology (F.M.A., A.H., M.S.A., N.N.A., M.A.) and the Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine (E.R.), Rigshospitalet Glostrup, University of Copenhagen, Denmark; the Department of Neurology (S.M.), University Hospital Basel, Switzerland; and the Department of Neurology (T.S.), DKD Helios Klinik Wiesbaden, Germany. ashina@dadlnet.dk.

PMID: 26674334
DOI: 10.1212/WNL.0000000000002261

Abstract

Objective: To investigate resting-state functional connectivity in the salience network (SN), the sensorimotor network (SMN), and the default mode network (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38).

Methods: In a double-blind, randomized study, 24 female migraine patients without aura received IV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related and cause vasodilation, but only PACAP38 induces migraine attacks. VIP was therefore used as active placebo. Resting-state functional MRI was recorded before and during PACAP38-induced migraine attacks and before and after VIP infusion. We analyzed data by Statistical Parametric Mapping 8 and the Resting-State fMRI Data Analysis Toolkit for Matlab in a seed-based fashion.

Results: PACAP38 (n = 16) induced migraine attacks and increased connectivity with the bilateral opercular part of the inferior frontal gyrus in the SN. In SMN, there was increased connectivity with the right premotor cortex and decreased connectivity with the left visual cortex. Several areas showed increased (left primary auditory, secondary somatosensory, premotor, and visual cortices) and decreased (right cerebellum and left frontal lobe) connectivity with DMN. We found no resting-state network changes after VIP (n = 15).

Conclusions: PACAP38-induced migraine attack is associated with altered connectivity of several large-scale functional networks of the brain.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain / drug effects
Brain / physiopathology
Brain Mapping / methods
Double-Blind Method
Female
Humans
Magnetic Resonance Imaging* / methods
Migraine Disorders / chemically induced*
Migraine Disorders / physiopathology
Nerve Net / drug effects*
Nerve Net / physiopathology*
Neurotransmitter Agents / adverse effects*
Pituitary Adenylate Cyclase-Activating Polypeptide / adverse effects*
Young Adult

Substances

Neurotransmitter Agents
Pituitary Adenylate Cyclase-Activating Polypeptide