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Nano Lett. 2016 Jan 13;16(1):766-72. doi: 10.1021/acs.nanolett.5b04731. Epub 2015 Dec 21.

Hierarchical Nanowire Arrays as Three-Dimensional Fractal Nanobiointerfaces for High Efficient Capture of Cancer Cells.

Zhang F1,2, Jiang Y1,2, Liu X1,2, Meng J3, Zhang P1,2, Liu H3, Yang G1,2, Li G1,2, Jiang L3,2, Wan LJ1,2, Hu JS1,2, Wang S3,2.

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Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
Laboratory of Bio-inspired Smart Interface Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.


A hierarchical assembled ITO nanowire array with both horizontal and vertical nanowire branches was fabricated as a new three-dimensional fractal nanobiointerface for efficient cancer cell capture. Comparing with ITO nanowire array without branches, this fractal nanobiointerface exhibited much higher efficiency (89% vs 67%) and specificity in capturing cancer cells and took shorter time (35 vs 45 min) to reach the maximal capture efficiency. As indicated by the immunofluorescent and ESEM images, this enhancement can be attributed to the improvement of topographical interaction between cells and the substrate. The introduction of horizontal and vertical nanowire branches makes the substrate topographically match better with cell filopodia and provides more binding sites for cell capture. The live/dead cell staining and proliferation experiments confirm that this fractal nanobiointerface displays excellent cyto-compatibility with an over 96% cell viability after capture. These results provide new insights and may open up opportunities in designing and engineering new cell-material interfaces for advanced biomedical applications.


Nanobiointerfaces; cell capture; cyto-compatibility; nanostructures; topographical interaction

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