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J Infect Dis. 2016 Jun 15;213(12):1914-22. doi: 10.1093/infdis/jiv597. Epub 2015 Dec 15.

Gastrointestinal Tract Colonization Dynamics by Different Enterococcus faecium Clades.

Author information

1
Department of Internal Medicine, Division of Infectious Diseases Center for the Study of Emerging and Re-emerging Pathogens Department of Microbiology and Molecular Genetics, University of Texas Graduate School of Biomedical Sciences at Houston, University of Texas Health Science Center at Houston.
2
Department of Internal Medicine, Division of Infectious Diseases Center for the Study of Emerging and Re-emerging Pathogens.

Abstract

Colonization of the gastrointestinal tract (GIT) generally precedes infection with antibiotic-resistant Enterococcus faecium We used a mouse GIT colonization model to test differences in the colonization levels by strains from different E. faecium lineages: clade B, part of the healthy human microbiota; subclade A1, associated with infections; and subclade A2, primarily associated with animals. After mono-inoculation, there was no significant difference in colonization (measured as the geometric mean number of colony-forming units per gram) by the E. faecium clades at any time point (P > .05). However, in competition assays, with 6 of the 7 pairs, clade B strains outcompeted clade A strains in their ability to persist in the GIT; this difference was significant in some pairs by day 2 and in all pairs by day 14 (P < .0008-.0283). This observation may explain the predominance of clade B in the community and why antibiotic-resistant hospital-associated E. faecium are often replaced by clade B strains once patients leave the hospital.

KEYWORDS:

Enterococcus faecium; GIT; clades; colonization; fitness

PMID:
26671890
PMCID:
PMC4878718
DOI:
10.1093/infdis/jiv597
[Indexed for MEDLINE]
Free PMC Article

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