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J Infect Dis. 2016 Apr 15;213(8):1340-7. doi: 10.1093/infdis/jiv587. Epub 2015 Dec 15.

Placental Infection With Ureaplasma species Is Associated With Histologic Chorioamnionitis and Adverse Outcomes in Moderately Preterm and Late-Preterm Infants.

Author information

1
Institute of Health and Biomedical Innovation, Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
2
Division of Neonatology.
3
Division of Maternal and Fetal Medicine.
4
Division of Immunobiology, Cincinnati Children's Hospital Medical Centre, Ohio.

Abstract

OBJECTIVE:

The human Ureaplasma species are the microbes most frequently isolated from placentae of women who deliver preterm. The role of Ureaplasma species has been investigated in pregnancies at <32 weeks of gestation, but currently no studies have determined the prevalence of ureaplasmas in moderately preterm and late-preterm (hereafter, "moderate/late preterm") infants, the largest cohort of preterm infants.

METHODS:

Women delivering moderate/late preterm infants (n = 477) and their infants/placentae (n = 535) were recruited, and swab specimens of chorioamnion tissue, chorioamnion tissue specimens, and cord blood specimens were obtained at delivery. Swab and tissue specimens were cultured and analyzed by 16S ribosomal RNA polymerase chain reaction (PCR) for the presence of microorganisms, while cord blood specimens were analyzed for the presence of cytokines, chemokines, and growth factors.

RESULTS:

We detected microorganisms in 10.6% of 535 placentae (443 were delivered late preterm and 92 were delivered at term). Significantly, Ureaplasma species were the most prevalent microorganisms, and their presence alone was associated with histologically confirmed chorioamnionitis in moderate/late preterm and term placentae (P < .001). The presence of ureaplasmas in the chorioamnion was also associated with elevated levels of granulocyte colony-stimulating factor (P = .02).

CONCLUSIONS:

These findings have important implications for infection and adverse pregnancy outcomes throughout gestation and should be of major consideration for obstetricians and neonatologists.

KEYWORDS:

Ureaplasma species; chorioamnionitis; cord blood; cytokines; infection; placenta; pregnancy outcomes; preterm birth

PMID:
26671889
PMCID:
PMC4799668
DOI:
10.1093/infdis/jiv587
[Indexed for MEDLINE]
Free PMC Article

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