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Eur J Cardiothorac Surg. 2016 Jul;50(1):180-2. doi: 10.1093/ejcts/ezv423. Epub 2015 Dec 15.

An uncommon cause of tricuspid regurgitation: three-dimensional echocardiographic incremental value, surgical and genetic insights.

Author information

1
Department of Cardiac Surgery, La Timone Hospital, Marseille, France Aix Marseille Université, GMGF 13385, Marseille, France Inserm, UMR_S910, 13385 Marseille, France.
2
Aix Marseille Université, GMGF 13385, Marseille, France Inserm, UMR_S910, 13385 Marseille, France.
3
Department of Cardiac Surgery, La Timone Hospital, Marseille, France.
4
Aix Marseille Université, GMGF 13385, Marseille, France Inserm, UMR_S910, 13385 Marseille, France stephane.zaffran@univ-amu.fr.

Abstract

Congenital tricuspid valve disease is a rare defect that includes regurgitation, stenosis and Ebstein's anomaly. We report a case of severe tricuspid regurgitation associated with functional mitral regurgitation in a 47-year-old man with congestive heart failure. Transthoracic echocardiography (TTE) ruled out any Ebstein's anomaly. Three-dimensional TTE revealed a 'tricuspid hole' into the anterior leaflet that was only attached to the tricuspid annulus next to both anteroseptal and anteroposterior commissures. There was no sign of leaflet tear or perforation. The surgical repair of the tricuspid and mitral valves was performed with an optimal result. No sign of endocarditis or rheumatic disease was observed during the intervention. Sequence analysis of GATA4, HEY2 and ZFPM2 genes was performed, but no causative mutation was identified.

KEYWORDS:

Echocardiography; Tricuspid valve; Valvular heart disease

PMID:
26670804
DOI:
10.1093/ejcts/ezv423
[Indexed for MEDLINE]

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