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J Physiol. 2016 Sep 1;594(17):4805-13. doi: 10.1113/JP271653. Epub 2016 Jan 18.

Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues.

Author information

1
Boston Children's Hospital, Boston, MA, 02115, USA.

Abstract

Long-lived and self-renewing adult stem cells (SCs) are essential for homeostasis in a wide range of tissues and can include both rapidly cycling and quiescent (q)SC populations. Rapidly cycling SCs function principally during normal tissue maintenance and are highly sensitive to stress, whereas qSCs exit from their quiescent state in response to homeostatic imbalance and regenerative pressure. The regulatory mechanisms underlying the quiescent state include factors essential for cell cycle control, stress response and survival pathways, developmental signalling pathways, and post-transcriptional modulation. Here, we review these regulatory mechanisms citing observations from the intestine and other self-renewing tissues.

PMID:
26670741
PMCID:
PMC5009802
DOI:
10.1113/JP271653
[Indexed for MEDLINE]
Free PMC Article

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