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Small. 2016 Jan 27;12(4):452-6. doi: 10.1002/smll.201502883. Epub 2015 Dec 15.

Submicrometer-Sized Thermometer Particles Exploiting Selective Nucleic Acid Stability.

Author information

1
Institute of Chemical and Bioengineering, ETH Zurich, Vladimir-Prelog-Weg, 8093, Zurich, Switzerland.

Abstract

Encapsulated nucleic acid selective damage quantification by real-time polymerase chain reaction is used as sensing mechanism to build a novel class of submicrometer size thermometer. Thanks to the high thermal and chemical stability, and the capability of storing the read accumulated thermal history, the sensor overcomes some of current limitations in small scale thermometry.

KEYWORDS:

deoxyribonucleic acid; nucleic acids; polymerase chain reactions; ribonucleic acid; silica; temperature

PMID:
26670705
DOI:
10.1002/smll.201502883
[Indexed for MEDLINE]

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