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Nat Rev Mol Cell Biol. 2016 Jan;17(1):41-54. doi: 10.1038/nrm.2015.7. Epub 2015 Dec 16.

The exon junction complex as a node of post-transcriptional networks.

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Ecole Normale Supérieure, Institut de Biologie de l'ENS (IBENS), Paris, F-75005, France.


The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a unique structure, which can both stably bind to mRNAs and function as an anchor for diverse processing factors. Recent findings revealed that in addition to its established roles in nonsense-mediated mRNA decay, the EJC is involved in mRNA splicing, transport and translation. While structural studies have shed light on EJC assembly, transcriptome-wide analyses revealed differential EJC loading at spliced junctions. Thus, the EJC functions as a node of post-transcriptional gene expression networks, the importance of which is being revealed by the discovery of increasing numbers of EJC-related disorders.

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