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Nature. 1989 Aug 10;340(6233):443-8.

Association of class I major histocompatibility heavy and light chains induced by viral peptides.

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1
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

Abstract

We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.

PMID:
2666863
DOI:
10.1038/340443a0
[Indexed for MEDLINE]
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