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Nat Rev Cancer. 2016 Jan;16(1):35-42. doi: 10.1038/nrc.2015.4. Epub 2015 Dec 15.

DNA repair, genome stability and cancer: a historical perspective.

Author information

1
Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton BN1 9RQ, UK.

Abstract

The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.

PMID:
26667849
DOI:
10.1038/nrc.2015.4
[Indexed for MEDLINE]

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