Format

Send to

Choose Destination
Nat Commun. 2015 Dec 15;6:10183. doi: 10.1038/ncomms10183.

Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes.

Author information

1
INSERM UMR 1043, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse F-31300, France.
2
CNRS UMR 5282, Toulouse F-31300, France.
3
Université Toulouse III Paul Sabatier, CHU Purpan BP 3028, Toulouse F-31300, France.
4
INSERM UMRS976 and Université Paris-Diderot, Hôpital Saint Louis, Paris 75010, France.
5
Service de Gynécologie-Obstétrique, Centre Hospitalo-Universitaire de Toulouse, Hôpital Paule de Viguier, Toulouse 31059, France.
6
Service de Gynécologie-Obstétrique Clinique Sarrus-Teinturiers, Toulouse 31300, France.

Abstract

The natural cytotoxicity receptors NKp46/NCR1, NKp44/NCR2 and NKp30/NCR3 are critical for natural killer (NK) cell functions. Their genes are transcribed into several splice variants whose physiological relevance is not yet fully understood. Here we report that decidua basalis NK (dNK) cells of the pregnant uterine mucosa and peripheral blood NK (pNK) cells, two functionally distinct subsets of the physiological NK cell pool, display differential expression of NKp30/NCR3 and NKp44/NCR2 splice variants. The presence of cytokines that are enriched within the decidual microenvironment is sufficient to convert the splice variant profile of pNK cells into one similar to that of dNK cells. This switch is associated with decreased cytotoxic function and major adaptations to the secretome, hallmarks of the decidual phenotype. Thus, NKp30/NCR3 and NKp44/NCR2 splice variants delineate functionally distinct NK cell subsets. To our knowledge, this is the first conclusive evidence underlining the physiological importance of NCR splice variants.

PMID:
26666685
PMCID:
PMC4682172
DOI:
10.1038/ncomms10183
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center