Format

Send to

Choose Destination
Nat Rev Genet. 2016 Jan;17(1):47-62. doi: 10.1038/nrg.2015.10.

Unique features of long non-coding RNA biogenesis and function.

Author information

1
Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California 94305, USA.
2
Department of Bioengineering, Stanford University School of Medicine and School of Engineering, Stanford, California 94305, USA.

Abstract

Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous biological processes across every branch of life. Although initially discovered as mRNA-like transcripts that do not encode proteins, recent studies have revealed features of lncRNAs that further distinguish them from mRNAs. In this Review, we describe special events in the lifetimes of lncRNAs - before, during and after transcription - and discuss how these events ultimately shape the unique characteristics and functional roles of lncRNAs.

PMID:
26666209
DOI:
10.1038/nrg.2015.10
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center