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eNeuro. 2015 Dec 3;2(6). pii: ENEURO.0083-15.2015. doi: 10.1523/ENEURO.0083-15.2015. eCollection 2015 Nov-Dec.

Neural Coding of Perceived Odor Intensity.

Author information

1
The Rockefeller University , New York, New York 10065.
2
Janelia Farm Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147 ; Sagol Department of Neurobiology, University of Haifa , Haifa 34905, Israel ; Institute of Neuroscience, University of Oregon , Eugene, OR 97405.
3
Janelia Farm Research Campus, Howard Hughes Medical Institute , Ashburn, Virginia 20147 ; NYU Neuroscience Institute, NYU Langone Medical Center , New York, New York 10016.

Abstract

Stimulus intensity is a fundamental perceptual feature in all sensory systems. In olfaction, perceived odor intensity depends on at least two variables: odor concentration; and duration of the odor exposure or adaptation. To examine how neural activity at early stages of the olfactory system represents features relevant to intensity perception, we studied the responses of mitral/tufted cells (MTCs) while manipulating odor concentration and exposure duration. Temporal profiles of MTC responses to odors changed both as a function of concentration and with adaptation. However, despite the complexity of these responses, adaptation and concentration dependencies behaved similarly. These similarities were visualized by principal component analysis of average population responses and were quantified by discriminant analysis in a trial-by-trial manner. The qualitative functional dependencies of neuronal responses paralleled psychophysics results in humans. We suggest that temporal patterns of MTC responses in the olfactory bulb contribute to an internal perceptual variable: odor intensity.

KEYWORDS:

Concentration versus adaptation; extracellular electrophysiology; human psychophysics; olfactory bulb

PMID:
26665162
PMCID:
PMC4672005
DOI:
10.1523/ENEURO.0083-15.2015
[Indexed for MEDLINE]
Free PMC Article

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