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Can Vet J. 2015 Dec;56(12):1252-6.

Evaluation of plasma inflammatory cytokine concentrations in racing sled dogs.

Author information

1
Surgical Services, Friendship Hospital for Animals, 4105 Brandywine Street NW, Washington, District of Columbia 20016, USA (von Pfeil); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1314, USA (von Pfeil); Department of Biomedical Sciences (Cummings), Department of Clinical Sciences (Loftus, Levine, Wakshlag), Department of Population Medicine (Mann), College of Veterinary Medicine, Cornell University, Ithaca, New York, USA; Annamaet Petfoods, Sellersville, Pennsylvania, USA (Downey); The Traveling Vet LLC, Loveland, Colorado, USA (Griffitts).

Abstract

in English, French

In human athletes significant changes in cytokine concentrations secondary to exercise have been observed. This prospective study evaluated the effect of a multi-day stage sled dog race on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). Samples from 20 dogs were harvested prior to and on days 2 and 8 of an 8-day race. Exercise resulted in significantly decreased TNF-α and IL-8 as well as increases of MCP-1, IL-6, and IL-10 concentrations (P-value between 0.01 and < 0.0001 for all parameters). The proportion of values for IL-2 that were below the detection limit increased from 40% on day 0 to 75% on day 2 and decreased on day 8 to 40% (P = 0.04). Racing sled dogs show cytokine-concentration changes that are different from those in humans.

PMID:
26663920
PMCID:
PMC4668826
[Indexed for MEDLINE]
Free PMC Article

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