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Acta Paediatr. 2016 Apr;105(4):358-65. doi: 10.1111/apa.13299. Epub 2016 Jan 25.

The neuroscience and context of adolescent depression.

Author information

1
Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California, San Francisco (UCSF), San Francisco, CA, USA.
2
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
3
Neurosciences Program and Department of Psychology, Stanford University, Stanford, CA, USA.
4
Department of Radiology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
5
The Osher Center for Integrative Medicine, University of California, San Francisco (UCSF), San Francisco, CA, USA.

Abstract

Adolescent depression is a growing public health concern with an increased risk of negative health outcomes, including suicide. The use of antidepressants and psychotherapy has not halted its increasing prevalence, and there is a critical need for effective prevention and treatment. We reviewed the neuroscience of adolescent depression, with a focus on the neurocircuitry of sustained threat and summarised contextual factors that have an impact on brain development and the pathophysiology of depression. We also reviewed novel treatment models.

CONCLUSION:

Attention to the relevant neurocircuitry and contextual factors implicated in adolescent depression is necessary to advance prevention and treatment development.

KEYWORDS:

Adolescent depression; Contextual factors; Neuroscience; Review; Sustained threat

PMID:
26663379
PMCID:
PMC4779656
DOI:
10.1111/apa.13299
[Indexed for MEDLINE]
Free PMC Article

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