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Low Urin Tract Symptoms. 2013 May;5(2):75-81. doi: 10.1111/j.1757-5672.2012.00173.x. Epub 2012 Sep 21.

Nocturia Potentially Influences Maintenance of Sexual Function in Elderly Men with Benign Prostatic Hyperplasia.

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Department of Urology, Shinshu University School of Medicine, MatsumotoDepartment of Urology, Graduate School of Medicine, Yamaguchi University, UbeDepartment of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, NagasakiDepartment of Urology, Hiroshima University Graduate School of Biomedical Sciences, HiroshimaDepartment of Urology, Faculty of Medicine, Yamagata University, YamagataDepartment of Urology, Nihon University School of Medicine, TokyoDepartment of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, YamanashiDepartment of Urology, Hamamatsu University School of Medicine, HamamatsuDepartment of Urology, Fujita Health University School of Medicine, ToyoakeDepartment of Urology, Kochi Medical School, KochiDepartment of Urology, Wakayama Medical University, WakayamaDepartment of Renal and Urologic Surgery, Asahikawa Medical University, AsahikawaDepartment of Urology, Sapporo Medical University School of Medicine, SapporoDepartment of Urology, Dokkyo Medical University, Tochigi, JapanDepartment of Urology, Faculty of Medical Science, University of Fukui, EiheijiDepartment of Urology, Kagawa University Faculty of Medicine, Kita-gun, Japan.



This study examined the relationship between bothersome symptoms of nocturia and erectile function.


Subjects comprised patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Patients were prospectively followed on treatment with the alpha-1 blocker naftopidil for 8 weeks. Patient backgrounds and efficacy of naftopidil associated with LUTS and sexual activity were evaluated.


The percentage of patients who identified nocturia as the most bothersome symptom was 30.2% (n = 135), representing the highest percentage among International Prostate Symptom Score (IPSS) items. The number of patients with nocturia as the most bothersome symptom plateaued at an IPSS for nocturia of two or three points. In contrast, the number of patients with slow stream as the most bothersome symptom increased with symptom severity according to IPSS for slow stream. Logistic regression analysis on association between nocturia and erectile function confirmed that the odds ratio was 1.41 (P < 0.05). Naftopidil showed excellent efficacy related to male LUTS, but International Index of Erectile Function 5 (IIEF5) total score was almost unchanged. Among patients with nocturia improved by naftopidil, IIEF5 total score was significantly changed in the group with IPSS nocturia score ≤1 as compared to the group with IPSS nocturia score ≥2 per night (P = 0.038).


Nocturia the most bothersome symptom correlated with aging. Nocturia could associate erectile dysfunction, and keeping the frequency of nocturia at ≤1 episode might be meaningful for maintaining quality of life in elderly men.


International Index of Erectile Function 5; benign prostatic hyperplasia; erectile dysfunction; male lower urinary tract symptoms; nocturia

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